幽门螺杆菌感染与缺血性脑卒中发病风险相关性的Meta分析

Objective To systematically evaluate the association between Helicobacter pylori (Hp) infection and ischemic stroke (IS). Methods The Cochrane library, CBM, CNKI, Wanfang and VIP databases were searched for observational studies on the relationship between Hp infection and the risk of IS from the establishment of the database to December 2020. Two researchers independently screened the literature, extracted information, and evaluated the quality and risk of bias of the included studies. Meta-analysis was performed with the use of Stata Software. Results A total of 26 comparisons involving 111 059 patients were included in 24 articles, including 19 case—control studies and seven cohort studies. The literature was of middle or high level. Results of this meta-analysis showed that Hp infection significantly increased the risk of IS [0R (95%£7) =1.52 (1.31-1.77), P<0.01]. Subgroup analyses showed that Hp infection was significantly related to IS [case—control study (OÄ = 1.69)], detection of infection [HP-IgG (0Ä = 1.42), CagA-IgG (OR=2.09), C-14 (Oft=3.30)], and the etiological Classification of stroke [large artery atherosclerotic (OR =2.69)]. Conclusion There is a significant correlation between Hp infection and IS, but this conclusion needs further confirmation by more high-quality etiological studies.