Poststroke depression in patients with small subcortical infarcts

Yangkun Chen; Xiangyan Chen; Vincent C.T. Mok; Wynnie W.M. Lam; Ka Sing Wong; Wai Kwong Tang

doi:10.1016/j.clineuro.2008.10.008

Poststroke depression in patients with small subcortical infarcts

Yangkun Chen
, Xiangyan Chen
, Vincent C.T. Mok
, Wynnie W.M. Lam
, Ka Sing Wong
, Wai Kwong Tang

Division of Science, Engineering and Health Studies (SEHS)

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Objectives: Small subcortical infarcts (SSIs) can result from small vessel disease (SVD) and intracranial and extracranial large artery disease (LAD). No study has explored poststroke depression (PSD) in different etiological types of SSIs. Methods: Patients with SSIs resulting from LAD and SVD were included in the study. Poststroke depression was evaluated with the 15-item version of the geriatric depression scale (GDS) 3 months after stroke. Results: Of the 127 patients with SSIs, 44 had LAD and 83 had SVD. The LAD group had a significantly higher mean GDS score and higher frequency of PSD (p < 0.05). The etiological type LAD was a significant independent risk factor for PSD. Conclusion: PSD is more common in patients with SSIs resulting from LAD. This suggests that cerebral blood perfusion may play an important role in the development of PSD.

Original language	English
Pages (from-to)	256-260
Number of pages	5
Journal	Clinical Neurology and Neurosurgery
Volume	111
Issue number	3
DOIs	https://doi.org/10.1016/j.clineuro.2008.10.008
Publication status	Published - Apr 2009

Keywords

Carotid artery stenosis
Depression
Intracranial large artery disease
MRI
Small vessel disease
Stroke

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10.1016/j.clineuro.2008.10.008

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title = "Poststroke depression in patients with small subcortical infarcts",

abstract = "Objectives: Small subcortical infarcts (SSIs) can result from small vessel disease (SVD) and intracranial and extracranial large artery disease (LAD). No study has explored poststroke depression (PSD) in different etiological types of SSIs. Methods: Patients with SSIs resulting from LAD and SVD were included in the study. Poststroke depression was evaluated with the 15-item version of the geriatric depression scale (GDS) 3 months after stroke. Results: Of the 127 patients with SSIs, 44 had LAD and 83 had SVD. The LAD group had a significantly higher mean GDS score and higher frequency of PSD (p < 0.05). The etiological type LAD was a significant independent risk factor for PSD. Conclusion: PSD is more common in patients with SSIs resulting from LAD. This suggests that cerebral blood perfusion may play an important role in the development of PSD.",

keywords = "Carotid artery stenosis, Depression, Intracranial large artery disease, MRI, Small vessel disease, Stroke",

author = "Yangkun Chen and Xiangyan Chen and Mok, \{Vincent C.T.\} and Lam, \{Wynnie W.M.\} and Wong, \{Ka Sing\} and Tang, \{Wai Kwong\}",

year = "2009",

month = apr,

doi = "10.1016/j.clineuro.2008.10.008",

language = "English",

volume = "111",

pages = "256--260",

journal = "Clinical Neurology and Neurosurgery",

issn = "0303-8467",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Poststroke depression in patients with small subcortical infarcts

AU - Chen, Yangkun

AU - Chen, Xiangyan

AU - Mok, Vincent C.T.

AU - Lam, Wynnie W.M.

AU - Wong, Ka Sing

AU - Tang, Wai Kwong

PY - 2009/4

Y1 - 2009/4

N2 - Objectives: Small subcortical infarcts (SSIs) can result from small vessel disease (SVD) and intracranial and extracranial large artery disease (LAD). No study has explored poststroke depression (PSD) in different etiological types of SSIs. Methods: Patients with SSIs resulting from LAD and SVD were included in the study. Poststroke depression was evaluated with the 15-item version of the geriatric depression scale (GDS) 3 months after stroke. Results: Of the 127 patients with SSIs, 44 had LAD and 83 had SVD. The LAD group had a significantly higher mean GDS score and higher frequency of PSD (p < 0.05). The etiological type LAD was a significant independent risk factor for PSD. Conclusion: PSD is more common in patients with SSIs resulting from LAD. This suggests that cerebral blood perfusion may play an important role in the development of PSD.

AB - Objectives: Small subcortical infarcts (SSIs) can result from small vessel disease (SVD) and intracranial and extracranial large artery disease (LAD). No study has explored poststroke depression (PSD) in different etiological types of SSIs. Methods: Patients with SSIs resulting from LAD and SVD were included in the study. Poststroke depression was evaluated with the 15-item version of the geriatric depression scale (GDS) 3 months after stroke. Results: Of the 127 patients with SSIs, 44 had LAD and 83 had SVD. The LAD group had a significantly higher mean GDS score and higher frequency of PSD (p < 0.05). The etiological type LAD was a significant independent risk factor for PSD. Conclusion: PSD is more common in patients with SSIs resulting from LAD. This suggests that cerebral blood perfusion may play an important role in the development of PSD.

KW - Carotid artery stenosis

KW - Depression

KW - Intracranial large artery disease

KW - MRI

KW - Small vessel disease

KW - Stroke

UR - https://www.scopus.com/pages/publications/60649091273

U2 - 10.1016/j.clineuro.2008.10.008

DO - 10.1016/j.clineuro.2008.10.008

M3 - Article

C2 - 19036495

AN - SCOPUS:60649091273

SN - 0303-8467

VL - 111

SP - 256

EP - 260

JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

IS - 3

ER -

Poststroke depression in patients with small subcortical infarcts

Abstract

Keywords

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