Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics

We report a prolonged wearable biosensing system for monitoring hyperuricemia (HUA), a prevalent metabolic disorder resulting from abnormal purine metabolism, from sweat, with reliable and stable behaviors for up to 15 days. This reusable wearable system integrates an interference-resistant HUA biosensor, a microfluidic module for autonomous sweat collection, a conformable device-skin adhesive interface with adjustable adhesion strength, and a flexible circuit board for data acquisition and transmission. A customized mobile application provides real-time HUA levels and associated risks, facilitating timely self-regulation and long-term dietary and health management. The HUA sensing signal of sweat was compared and calibrated with clinical standard by serum tests for 80 volunteers, where the results exhibited great correlation and thus can be used as assessing criteria. On-body tracking validation further highlighted the great potential of our wearable bioelectronics for the development of individualized diagnostic protocols.